Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action

A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-08, Vol.20 (16), p.5046-5052
Hauptverfasser:	Fioravanti, Rossella, Celestino, Ignacio, Costi, Roberta, Cuzzucoli Crucitti, Giuliana, Pescatori, Luca, Mattiello, Leonardo, Novellino, Ettore, Checconi, Paola, Palamara, Anna Teresa, Nencioni, Lucia, Santo, Roberto Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral Agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology antiviral properties Antivirals Biological and medical sciences Cell Line Curcumin Dogs Dose-Response Relationship, Drug Hemagglutinins Influenza Influenza A virus Influenza A virus - drug effects Influenza A virus - growth & development Life Sciences MAP kinase mechanism of action Medical sciences Microbial Sensitivity Tests mitogen-activated protein kinase Molecular Structure Orthomyxoviridae Oxidation-Reduction Pharmaceutical sciences Pharmacology. Drug treatments Polyphenols Polyphenols - chemical synthesis Polyphenols - chemistry Polyphenols - pharmacology Replication Resveratrol Ribonucleoproteins Structure-Activity Relationship Toxicity Virus Replication Virus Replication - drug effects
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Zusammenfassung:	A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2012.05.062