Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease

Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease

Abstract We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5′-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphis...

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Veröffentlicht in:Diabetes research and clinical practice 2010-02, Vol.87 (2), p.e7-e10
Hauptverfasser: Nouira, S, Arfa, I, Kammoun, I, Abid, A, Ouragini, H, Dorboz, I, Ghazouani, W, Fadhel, S. Ben, Zorgati, M.M, Ammar, S. Ben, Blousa-Chabchoub, S, Kachboura, S, Abdelhak, S
Format: Artikel
Sprache:eng
Schlagworte:
5' Untranslated Regions
5' Untranslated Regions - genetics
5′-AMP-activated protein kinase (AMPK)
Age of Onset
Aged
AMP-Activated Protein Kinases
AMP-Activated Protein Kinases - genetics
Base Sequence
Cardiac failure
Cardiovascular Diseases
Cardiovascular Diseases - genetics
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetic Angiopathies
Diabetic Angiopathies - genetics
Endocrinology & Metabolism
Exons
Exons - genetics
Genetic Variation
Humans
Medical History Taking
Middle Aged
Molecular Sequence Data
Polymorphism, Single Nucleotide
Reference Values
Sequence Alignment
Sequence Homology, Nucleic Acid
SNP
Tunisia
Type 2 diabetes
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Zusammenfassung:Abstract We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5′-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2009.11.009