A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors

A novel depolarizing activity of scorpion venom fraction M1 due to activation of skeletal muscle nicotinic receptors

A depolarizing activity following interaction with nicotinic acetylcholine receptors (nAchRs) in skeletal muscle cells, was observed for the first time in the non-toxic venom fraction (M1) of the yellow scorpion Buthus occitanus tunetanus (Bot). The effects of M1 fraction were tested on cultured rat...

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Veröffentlicht in:Toxicon (Oxford) 2007, Vol.49 (1), p.117-122
Hauptverfasser: Cheikh, Amani, Benkhalifa, Rym, Potreau, Daniel, Raymond, Guy, El Ayeb, Mohamed, Cognard, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Animal poisons toxicology. Antivenoms
Animals
Biological and medical sciences
Buthus occitanus tunetanus
Calcium Channels
Calcium Channels - drug effects
Calcium Channels - metabolism
Calcium transient
Confocal microscopy
Excitation–contraction coupling
Medical sciences
Muscle Fibers, Skeletal
Muscle Fibers, Skeletal - drug effects
Muscle Fibers, Skeletal - metabolism
Muscle, Skeletal
Muscle, Skeletal - cytology
Nicotinic acetylcholine receptor agonists
Rats
Receptors, Nicotinic
Receptors, Nicotinic - drug effects
Receptors, Nicotinic - metabolism
Scorpion venom
Scorpion Venoms
Scorpion Venoms - pharmacology
Scorpions
Skeletal muscle
Toxicology
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Zusammenfassung:A depolarizing activity following interaction with nicotinic acetylcholine receptors (nAchRs) in skeletal muscle cells, was observed for the first time in the non-toxic venom fraction (M1) of the yellow scorpion Buthus occitanus tunetanus (Bot). The effects of M1 fraction were tested on cultured rat myotubes by recording changes in [Ca 2+]i. When applied, M1 (10 μg/mL) induced a transient increase of [Ca 2+] i which could be blocked by a prior application of α-Bungarotoxin ( α-Bg-Tx).
ISSN:0041-0101
1879-3150
0041-0101
DOI:10.1016/j.toxicon.2006.09.011