Sustained elevation of calprotectin associates with delayed appearance of myeloid-derived suppressor cells in patients with septic shock

[...]at day 5-7, we found a significantly correlation between increased calprotectin concentration and MDSC induction (r = 0.55, p < 0.007, Fig. 1D) whereas there was no correlation at earlier time points (Day1-2, r: 0.09, p: 0.53; day 3-4, r: - 0.06, p: 0.96). [...]it should be noted that at the transcriptomic level, S100A9 mRNA is increased in subsets of suppressive myeloid cells [4], and its persistence at elevated levels in circulation is associated with the occurrence of nosocomial infection and immunosuppression [5]. According to EFS standardized procedures for blood donation and to provisions of the articles R.1243–49 and following those of the French public health code, a written non-opposition to the use of donated blood for research purposes was obtained from HV (n = 15).