Validation of a non-targeted method devoted to identification and quantitation of toxicologically relevant compounds in plasma with HRMS

•High resolution mass spectrometry (HRMS) arouse a growing interest in toxicology.•All in one analytical method allowing an untargeted screening along with quantification of drugs of abuse (DoA) including natural cannabinoids.•Simple and fast sample pre-treatment using QuEChERS salts.•High sensitivi...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2023-05, Vol.1224, p.123739-123739, Article 123739
Hauptverfasser:	Becam, Jenny, Pelissier-Alicot, Anne-Laure, Doudka, Natalia, Richez, Magali, Solas, Caroline, Fabresse, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cannabinoids Chromatography, High Pressure Liquid - methods Chromatography, Liquid Forensic toxicology High resolution mass spectrometry Humans Life Sciences Limit of Detection Mass Spectrometry - methods Orbitrap Plasma QuEChERS Reproducibility of Results Santé publique et épidémiologie Toxicology
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Beschreibung
Zusammenfassung:	•High resolution mass spectrometry (HRMS) arouse a growing interest in toxicology.•All in one analytical method allowing an untargeted screening along with quantification of drugs of abuse (DoA) including natural cannabinoids.•Simple and fast sample pre-treatment using QuEChERS salts.•High sensitivity with a mean limit of identification (LOI) 0.99, intra- and inter-day accuracy and precision were
ISSN:	1570-0232 1873-376X
DOI:	10.1016/j.jchromb.2023.123739