Association between household cleaning product exposure in infancy and development of recurrent wheeze and asthma

Objective: Household chemicals may act as irritants in the lungs, however their association with recurrent wheeze and asthma in children remains controversial. We aimed to investigate if household cleaning product exposure in infancy is associated with recurrent wheezing and asthma development in children. Methods: We analyzed data from two cohorts: MARC-35 consisting of 815 children with history of severe bronchiolitis in infancy, and MARC-43 consisting of 525 healthy children in infancy. Frequency of use of cleaning product at the child's home during infancy was collected via telephone interview with parents. Outcomes were recurrent wheezing by age 3 years and asthma diagnosis at age 6 years. Results: In MARC-35, there was no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR= 1.01 [95% CI 0.66-1.54] for 4-7 days/week exposure frequency), nor asthma (adjusted OR= 0.91 [95% CI 0.51-1.63]). In MARC-43, there was also no association between cleaning product exposure in infancy and recurrent wheeze (adjusted HR= 0.69 [95% CI 0.29-1.67] for 4-7 days/week exposure frequency). Conclusions: We found no association between household cleaning product exposure in infancy and later development of recurrent wheeze or asthma, even among children who are high-risk for asthma due to history of severe bronchiolitis.