Nonskeletal and skeletal effects of high doses versus low doses of vitamin D3 in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial

Vitamin D sufficiency is associated with a reduced risk of fractures, diabetes mellitus, cardiovascular events, and cancers, which are frequent complications after renal transplantation. The VITALE (VITamin D supplementation in renAL transplant recipients) study is a multicenter double-blind randomi...

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Veröffentlicht in:	American journal of transplantation 2023-03, Vol.23 (3), p.366-376
Hauptverfasser:	Courbebaisse, Marie, Bourmaud, Aurelie, Souberbielle, Jean-Claude, Sberro-Soussan, Rebecca, Moal, Valérie, Le Meur, Yannick, Kamar, Nassim, Albano, Laetitia, Thierry, Antoine, Dantal, Jacques, Danthu, Clément, Moreau, Karine, Morelon, Emmanuel, Heng, Anne-Elisabeth, Bertrand, Dominique, Arzouk, Nadia, Perrin, Peggy, Morin, Marie-Pascale, Rieu, Philippe, Presne, Claire, Grimbert, Philippe, Ducloux, Didier, Büchler, Matthias, Le Quintrec, Moglie, Ouali, Nacéra, Pernin, Vincent, Bouvier, Nicolas, Durrbach, Antoine, Alamartine, Eric, Randoux, Christine, Besson, Virginie, Hazzan, Marc, Pages, Justine, Colas, Sandra, Piketty, Marie-Liesse, Friedlander, Gérard, Prié, Dominique, Alberti, Corinne, Thervet, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cardiovascular Diseases / etiology Cholecalciferol / adverse effects clinical research/practice clinical trial complication: malignant complication: medical/metabolic Dietary Supplements Double-Blind Method Humans hyperparathyroidism kidney disease: metabolic Kidney Transplantation / adverse effects kidney transplantation/nephrology Life Sciences Male Vitamin D / therapeutic use Vitamin D Deficiency / complications Vitamin D Deficiency / drug therapy Vitamins / adverse effects
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Zusammenfassung:	Vitamin D sufficiency is associated with a reduced risk of fractures, diabetes mellitus, cardiovascular events, and cancers, which are frequent complications after renal transplantation. The VITALE (VITamin D supplementation in renAL transplant recipients) study is a multicenter double-blind randomized trial, including nondiabetic adult renal transplant recipients with serum 25-hydroxy vitamin D (25(OH) vitamin D) levels of
ISSN:	1600-6135 1600-6143
DOI:	10.1016/j.ajt.2022.12.007