Evidence-based recommendations for the practical management of Familial Mediterranean Fever
Abstract Aim Familial Mediterranean Fever (FMF) is the most common recurrent autoinflammatory fever syndrome. Still, many issues—e.g.: colchicine dosage adjustment, maximum dosage of colchicine in children and adults, definition of colchicine resistance, alternative treatment solutions in colchicine...
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Veröffentlicht in: | Seminars in arthritis and rheumatism 2013-12, Vol.43 (3), p.387-391 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Aim Familial Mediterranean Fever (FMF) is the most common recurrent autoinflammatory fever syndrome. Still, many issues—e.g.: colchicine dosage adjustment, maximum dosage of colchicine in children and adults, definition of colchicine resistance, alternative treatment solutions in colchicine-resistant patients, and genetic screening for asymptomatic siblings—have not yet been standardized. The current paper aims at summarizing consensus recommendations to approach these issues. Methods A literature review concerning these practical management questions was performed through PubMed. On the basis of this analysis, expert recommendations were developed during a consensus meeting of caregivers from France and Israel. Results A patient experiencing more than four FMF attacks a year needs colchicine dose adjustment. In case of persistent attacks (≥6 per year) in patients with maximum doses of colchicine (2 mg in children; 3 mg in adults), alternative treatment to colchicine with IL1 inhibitors should be considered. Routine genetic testing for MEFV mutations in asymptomatic siblings of an index case is not recommended. Conclusion This is a first attempt to resolve practical questions in the daily management of FMF patients. |
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ISSN: | 0049-0172 1532-866X |
DOI: | 10.1016/j.semarthrit.2013.04.011 |