Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers
Non‐natural born killers: The addition of phosphorus‐containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2007-03, Vol.46 (14), p.2523-2526 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Griffe, Laurent Poupot, Mary Marchand, Patrice Maraval, Alexandrine Turrin, Cédric-Olivier Rolland, Olivier Métivier, Pascal Bacquet, Gérard Fournié, Jean-Jacques Caminade, Anne-Marie Poupot, Rémy Majoral, Jean-Pierre |
| description | Non‐natural born killers: The addition of phosphorus‐containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play a key role in anticancer immunity. Both the generation of the dendrimer and the type of end groups are important criteria for the activity. |
| doi_str_mv | 10.1002/anie.200604651 |
| format | Article |
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| subjects | biological activity Dendrimers Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology Hematology Human health and pathology Humans immunology Killer Cells, Natural Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Life Sciences Nanoparticles Nanoparticles - chemistry NK cells Organophosphonates Organophosphonates - chemistry phosphonates |
| title | Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers |
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