Multiplication of Human Natural Killer Cells by Nanosized Phosphonate-Capped Dendrimers

Non‐natural born killers: The addition of phosphorus‐containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-03, Vol.46 (14), p.2523-2526
Hauptverfasser: Griffe, Laurent, Poupot, Mary, Marchand, Patrice, Maraval, Alexandrine, Turrin, Cédric-Olivier, Rolland, Olivier, Métivier, Pascal, Bacquet, Gérard, Fournié, Jean-Jacques, Caminade, Anne-Marie, Poupot, Rémy, Majoral, Jean-Pierre
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Sprache:eng
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Zusammenfassung:Non‐natural born killers: The addition of phosphorus‐containing dendrimers capped with phosphonate end groups to cultures of human peripheral blood mononuclear cells (white blood cells) strongly stimulates the selective multiplication of functional natural killer (NK) cells (see picture), which play a key role in anticancer immunity. Both the generation of the dendrimer and the type of end groups are important criteria for the activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604651