Dendrimers ended by non-symmetrical azadiphosphonate groups: Synthesis and immunological properties

The synthesis and characterization of new series of phosphorus-containing dendrimers ended by non-symmetrical azamonophosphonates, or azadiphosphonates, or azadiphosphonic acid salts are reported. The sodium salts of the non-symmetrical azadiphosphonic dendrimers are soluble in water. Their influenc...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-07, Vol.19 (14), p.3963-3966
Hauptverfasser:	Marchand, Patrice, Griffe, Laurent, Poupot, Mary, Turrin, Cédric-Olivier, Bacquet, Gérard, Fournié, Jean-Jacques, Majoral, Jean-Pierre, Poupot, Rémy, Caminade, Anne-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation of monocytes Aza Compounds - chemistry Biological and medical sciences Cells, Cultured Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology Hematology Human health and pathology Humans Immunology Immunomodulators Life Sciences Medical sciences Monocytes - drug effects Monocytes - immunology Organophosphonates - chemistry PBMC Pharmacology. Drug treatments Phosphonates Synthesis
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Beschreibung
Zusammenfassung:	The synthesis and characterization of new series of phosphorus-containing dendrimers ended by non-symmetrical azamonophosphonates, or azadiphosphonates, or azadiphosphonic acid salts are reported. The sodium salts of the non-symmetrical azadiphosphonic dendrimers are soluble in water. Their influence towards human immune blood cells is assayed ex vivo.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.03.003