A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer’s disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed widespread acetylomic variation associated with AD neuropatho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2018-11, Vol.21 (11), p.1618-1627
Hauptverfasser:	Marzi, Sarah J., Leung, Szi Kay, Ribarska, Teodora, Hannon, Eilis, Smith, Adam R., Pishva, Ehsan, Poschmann, Jeremie, Moore, Karen, Troakes, Claire, Al-Sarraj, Safa, Beck, Stephan, Newman, Stuart, Lunnon, Katie, Schalkwyk, Leonard C., Mill, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/23 38/43 38/90 631/208/177 692/699/375/132/1283 Acetylation Advertising executives Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Care and treatment Chromatin Cortex (entorhinal) Development and progression Disease control Entorhinal cortex Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Genes Genetic aspects Genetic Predisposition to Disease Genetic variation Genomes Genomics Heritability Histones - metabolism Humans Immunoprecipitation Life Sciences Lysine Male Medical research Middle Aged Neurobiology Neuropathology Neurosciences Risk factors Tau protein tau Proteins - genetics tau Proteins - metabolism Transcription Transcription (Genetics)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer’s disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed widespread acetylomic variation associated with AD neuropathology, identifying 4,162 differential peaks (false discovery rate
ISSN:	1097-6256 1546-1726
DOI:	10.1038/s41593-018-0253-7