Ion transport and signalling in human labial glands

Recent reports characterizing the physiological properties of normal human labial acini are reviewed with particular emphasis on mechanisms related to fluid secretion. In contrast to the salivary glands of several experimental animals, human labial acinar cells do not appear to have a1-adrenergic re...

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Veröffentlicht in:	Archives of oral biology 1999-05, Vol.44 Suppl 1, p.S15-S19
Hauptverfasser:	Turner, R J, Paulais, M, Valdez, I I, Evans, R L, Fox, P C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Calcium Channels - metabolism Calcium Signaling - physiology Carbonates - metabolism Cellular Biology Chloride Channels - metabolism Chlorides - metabolism Dentistry Humans Ion Transport - physiology Life Sciences Lip - anatomy & histology Molecular biology Potassium Channels - metabolism Receptors, Adrenergic, alpha - analysis Receptors, Muscarinic - metabolism Receptors, Neurokinin-1 - analysis Saliva - metabolism Salivary Glands, Minor - metabolism Signal Transduction - physiology Sodium Channels - metabolism Subcellular Processes
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Zusammenfassung:	Recent reports characterizing the physiological properties of normal human labial acini are reviewed with particular emphasis on mechanisms related to fluid secretion. In contrast to the salivary glands of several experimental animals, human labial acinar cells do not appear to have a1-adrenergic receptors, substance P peptidergic receptors, or significant levels of Cl-/HCO3- exchange. Nor do they appear to secrete HCO3- in response to Ca2+ mobilizing stimuli. The data presently available indicates that fluid secretion by these glands is mainly under muscarinic control and is due to acinar Cl- secretion driven by a basolateral Na+ -K+ -2Cl- cotansporter.
ISSN:	0003-9969
DOI:	10.1016/S0003-9969(99)00044-8