Factor H Autoantibodies and Membranous Nephropathy

The authors of this research letter describe a case of rapidly progressive renal failure in a patient with membranous nephropathy, related to the appearance of antibodies against the complement regulatory protein, factor H. Inhibition of factor H led to hyperactivation of the alternative complement...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-12, Vol.379 (25), p.2479-2481
Hauptverfasser:	Seikrit, Claudia, Ronco, Pierre, Debiec, Hanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies Autoantibodies - blood Autoantibodies - metabolism Biochemistry, Molecular Biology Biopsy Complement factor H Complement Factor H - immunology Complement Pathway, Alternative - physiology Enzyme-Linked Immunosorbent Assay Genomics Glomerulonephritis, Membranous - blood Glomerulonephritis, Membranous - immunology Humans Immunoglobulin G - metabolism Immunoglobulins Life Sciences Male Membranous nephropathy Middle Aged Nephropathy Patients Receptors, Phospholipase A2 - immunology Renal failure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The authors of this research letter describe a case of rapidly progressive renal failure in a patient with membranous nephropathy, related to the appearance of antibodies against the complement regulatory protein, factor H. Inhibition of factor H led to hyperactivation of the alternative complement pathway.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc1805857