Evaluation of a new random-access HBV DNA molecular assay: The VERIS HBV assay

Highlights • The evaluation of the VERIS random-access system for HBV quantification showed that the assay is sensitive, specific, and precise for HBV DNA detection and quantification; that the results are reproducible; and that its broad dynamic range of quantification is well suited to HBV DNA mon...

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Veröffentlicht in:	Journal of clinical virology 2017-07, Vol.92, p.69-74
Hauptverfasser:	Fourati, Slim, Challine, Dominique, Poveda, Jean-Dominique, Laperche, Syria, Rallier, Sandrine, Pawlotsky, Jean-Michel, Chevaliez, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology DNA, Viral - blood DNA, Viral - genetics Genotype Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - blood Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Infectious Disease Life Sciences Limit of Detection Molecular Diagnostic Techniques Polymerase Chain Reaction Reagent Kits, Diagnostic Sensitivity and Specificity Viral Load - methods
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Zusammenfassung:	Highlights • The evaluation of the VERIS random-access system for HBV quantification showed that the assay is sensitive, specific, and precise for HBV DNA detection and quantification; that the results are reproducible; and that its broad dynamic range of quantification is well suited to HBV DNA monitoring in the clinical setting. • This approach may represent a powerful tool that will make it possible to diagnose and monitor HBV infections, possibly in an emergency context such as that of organ, tissue and cell donor screening prior to transplantation.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2017.05.015