Interaction network linking the human H3N2 influenza A virus genomic RNA segments

Highlights ► The 8 vRNPs form a transition zone at the budding tip of the influenza A H3N2 virions. ► Contacts between vRNPs are observed in this transition zone. ► In vitro , all vRNAs are involved in a single interaction network. ► Sequences encompassing the packaging signals are involved in these...

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Veröffentlicht in:	Vaccine 2012-12, Vol.30 (51), p.7359-7367
Hauptverfasser:	Fournier, Emilie, Moules, Vincent, Essere, Boris, Paillart, Jean-Christophe, Sirbat, Jean-Daniel, Cavalier, Annie, Rolland, Jean-Paul, Thomas, Daniel, Lina, Bruno, Isel, Catherine, Marquet, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Binding sites Budding direct contact Electron Microscope Tomography Evolution Genetics genome Genome packaging Genomes genomics Humans Imaging, Three-Dimensional influenza Influenza A Influenza A virus Influenza A Virus, H3N2 Subtype Influenza A Virus, H3N2 Subtype - physiology Influenza A Virus, H3N2 Subtype - ultrastructure Influenza, Human Influenza, Human - virology Laboratories Life Sciences Mathematical models Microscopy Nucleoproteins Nucleoproteins - metabolism Orthomyxoviridae Packaging Protein Interaction Maps Ribonucleoproteins RNA RNA viruses RNA, Viral RNA, Viral - metabolism RNA/RNA interactions Segmentation Supramolecular complex Tomography Transition zone vaccines Viral Proteins Viral Proteins - metabolism virion Virions Virus Assembly Viruses
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Beschreibung
Zusammenfassung:	Highlights ► The 8 vRNPs form a transition zone at the budding tip of the influenza A H3N2 virions. ► Contacts between vRNPs are observed in this transition zone. ► In vitro , all vRNAs are involved in a single interaction network. ► Sequences encompassing the packaging signals are involved in these interactions. ► Our data suggest that these interactions play a role in the selective packaging of the vRNPs.
ISSN:	0264-410X 1873-2518 0264-410X
DOI:	10.1016/j.vaccine.2012.09.079