Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann–Finkelstein tandem reaction

Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann–Finkelstein tandem reaction

A new Ullmann–Finkelstein tandem reaction for the preparation of N-(iodophenyl)-amides is described. Using a new Ullmann–Finkelstein tandem reaction, N-(iodophenyl)-amides were synthesized from the corresponding amides and iodo-bromobenzenes. The catalyst/ligand couple CuI/ N, N′-dimethyl-cyclohexan...

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Veröffentlicht in:Tetrahedron letters 2006-02, Vol.47 (7), p.1181-1186
Hauptverfasser: Toto, Patrick, Gesquière, Jean-Claude, Deprez, Benoit, Willand, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Life Sciences
Pharmaceutical sciences
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Zusammenfassung:A new Ullmann–Finkelstein tandem reaction for the preparation of N-(iodophenyl)-amides is described. Using a new Ullmann–Finkelstein tandem reaction, N-(iodophenyl)-amides were synthesized from the corresponding amides and iodo-bromobenzenes. The catalyst/ligand couple CuI/ N, N′-dimethyl-cyclohexane-1,2-diamine was used for this reaction in dioxane with K 3PO 4 as base.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2005.12.022