Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Abstract A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for test...

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Veröffentlicht in:Scientific reports 2021-07, Vol.11 (1)
Hauptverfasser: Bal, Antonin, Brengel-Pesce, Karen, Gaymard, Alexandre, Quéromès, Grégory, Guibert, Nicolas, Frobert, Emilie, Bouscambert, Maude, Trabaud, Mary-Anne, Allantaz-Frager, Florence, Oriol, Guy, Cheynet, Valérie, D’aubarede, Constance, Massardier-Pilonchery, Amélie, Buisson, Marlyse, Lupo, Julien, Pozzetto, Bruno, Poignard, Pascal, Lina, Bruno, Fassier, Jean-Baptiste, Morfin, Florence, Trouillet-Assant, Sophie, Adnot, Jerôme, Alfaiate, Dulce, Bergeret, Alain, Boibieux, André, Bonnet, Florent, Brunel-Dalmas, Florence, Caire, Eurydice, Charbotel, Barbara, Chiarello, Pierre, Cotte, Laurent, Durupt, François, Escuret, Vanessa, Fascia, Pascal, Fontaine, Juliette, Gaillot-Durand, Lucie, Gillet, Myriam, Godinot, Matthieu, Gueyffier, François, Josset, Laurence, Lahousse, Matthieu, Lozano, Hélène, Makhloufi, Djamila, Milon, Marie-Paule, Moll, Frédéric, Narbey, David, Nazare, Julie-Anne, Oria, Fatima, Perry, Marielle, Pitiot, Virginie, Prudent, Mélanie, Rabilloud, Muriel, Samperiz, Audrey, Schlienger, Isabelle, Simon, Chantal, Valette, Martine
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Sprache:eng
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Zusammenfassung:Abstract A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs ( p = 0.07). The proportion of HCWs with a viral load > 5.0 log 10 cp/mL (Ct value  37). More than 90% of cultivable virus had a viral load > 4.5 log 10 cp/mL (Ct 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-93828-y