Template Assembled Synthetic Proteins (TASP) as Functional Mimetics of Proteins

Template Assembled Synthetic Proteins (TASP) as Functional Mimetics of Proteins

The bare essentials of a functional protein are all that are retained when the structural domain of a native protein is replaced by a synthetic template molecule (see picture below). New strategies for the synthesis of this novel type of template‐assembled synthetic peptide (TASP) provide functional...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-07, Vol.35 (13-14), p.1482-1485
Hauptverfasser: Mutter, Manfred, Dumy, Pascal, Garrouste, Patrick, Lehmann, Christian, Mathieu, Marc, Peggion, Cristina, Peluso, Stéphane, Razaname, Alain, Tuchscherer, Gabriele
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
protein mimetics
template syntheses
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Zusammenfassung:The bare essentials of a functional protein are all that are retained when the structural domain of a native protein is replaced by a synthetic template molecule (see picture below). New strategies for the synthesis of this novel type of template‐assembled synthetic peptide (TASP) provide functional mimetics of receptors and antibodies.
ISSN:0570-0833
1433-7851
1521-3773
DOI:10.1002/anie.199614821