Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT4) based on data collected from a disease-free sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplémentation en Vitamines et Minéraux Antioxyda...
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Veröffentlicht in: | Clinical chemistry and laboratory medicine 2009, Vol.47 (12), p.1497-1505 |
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Sprache: | eng |
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Zusammenfassung: | Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT4) based on data collected from a disease-free sample of French middle-aged adults. Methods: A total of 3218 subjects participating in the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35–60 years and 1025 males aged 45–60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT4 was estimated in males and females. Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29–5.21 mU/L) for ages 35–44 years and 1.98 mU/L (0.27–6.94 mU/L) for ages 45–60 years (p |
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ISSN: | 1434-6621 1437-4331 |
DOI: | 10.1515/CCLM.2009.334 |