Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study

Nirsevimab, a long-acting monoclonal antibody, has been approved for the prevention of respiratory syncytial virus (RSV) infection in infants. In France, more than 210 000 single doses were administered in infants younger than 1 year during the 2023–24 season. In this context, the selection and spre...

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Veröffentlicht in:	The Lancet infectious diseases 2024-10
Hauptverfasser:	Reslan, Alawiya, Casalegno, Jean-Sébastien, Chollet, Lionel, Pillet, Sylvie, Tremeaux, Pauline, Salmona, Maud, Imbert-Marcille, Berthe-Marie, Larrat, Sylvie, Marot, Stéphane, Stephan, Valentin, Brichler, Ségolène, Jaffar-Bandjee, Marie-Christine, Francois, Catherine, Hartard, Cédric, Dos Santos, Georges, Simon-Loriere, Etienne, Schwartz, Olivier, Buchrieser, Julian, Pawlotsky, Jean-MiIchel, Lemoine, Frédéric, Audureau, Etienne, Rameix-Welti, Marie-Anne, Zemali, Naël, Moisan, Alice, Zavaoarisaina, Zakasoa-Mbololona, Avettand-Fenoel, Véronique, Guillaume, Clémence, Mchantaf, Gilbert, Marie, Victoria, Bret, Laurent, Lesne, Fabien, Alidjinou, Kazali, de Pontual, Loic, Aupiais, Camille, Perrier, Marine, Jatteau, Pierre, Fofana, Djeneba, Cocherie, Théophile, Soulié, Cathia, Faisant, Anne, Tournegros, Caroline, Bourlet, Thomas, Bouthry, Elise, Warnakulasuriya, Fairly, Jaffar, Marie-Christine, Heaugwane, Diana, Azemar, Benjamin, Castelain, Sandrine, Rames, Cinthia, Bécourt, Arnaud, Foulongne, Vincent, Domitien, Léa, Handala, Lynda, Gaudy-Graffin, Catherine, Crémadés, Agathe, Gabassi, Audrey, Néré, Marie-Laure, Bonacorsi, Stéphane, Ouldali, Naim, Reslan, Alawyia, Bourret, Jérome, Yab, Emilie, Enouf, Vincent, Donati, Flora, Prot, Matthieu, Jeyarajah, Banujaa, Dossou, Nefert Candace, Vabret, Astrid, Rodriguez, Christophe, Cappy, Pierre, Soulier, Alexandre, Ader, Mohamed, Natella, Pierre-André, Fagour, Laurence, Schapira, Anne-Julie, Leveque, Nicolas, Morton Fauche, Claire, Castain, Louise, Rodallec, Audreay, Gras-le Guen, Christele, Chauvire-Drouard, Anne, Deback, Claire, Solis, Morgane, Gaitan, Léa, Mirand, Audrey, Thibault, Vincent, Trémeaux, Pauline, Claudet, Isabelle, Pucelle, Mélanie, Vellas, Camille, Veyrenche, Nicolas, Gaymard, Alexandre, Kombou, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Human health and pathology Life Sciences Pulmonology and respiratory tract
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Zusammenfassung:	Nirsevimab, a long-acting monoclonal antibody, has been approved for the prevention of respiratory syncytial virus (RSV) infection in infants. In France, more than 210 000 single doses were administered in infants younger than 1 year during the 2023–24 season. In this context, the selection and spread of escape variants might be a concern. Here, we aimed to characterise RSV associated with breakthrough infection. We did a multicentre, national, observational study in France during the 2023–24 RSV season in RSV-infected infants (aged
ISSN:	1473-3099 1474-4457 1474-4457
DOI:	10.1016/S1473-3099(24)00570-X