The adipose tissue that surrounds the prostate gland exhibits traits of hypoxic state that could contribute to its role in prostate cancer progression

Introduction & Objectives: The prostate gland is surrounded by periprostatic adipose tissue (PPAT), whose role in prostate cancer (PCa)progression has been recently revealed by several teams including ours (Laurent et al, Nature Comm, 2016; Mol Cancer Res, 2019). However,this specific adipose depot is poorly described, a lack of characterization that hinders the definition of its role in tumor progression. Our goal wasto characterize the tissue and cellular organization of PPAT as well as its functional capacities in comparison to paired perivesical adipose tissue(PVAT), an adipose depot at proximity to the bladder.