Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review
Purpose of Review Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and...
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Veröffentlicht in: | Current psychiatry reports 2024-03, Vol.26 (3), p.78-103 |
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description | Purpose of Review
Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and “Aged, 80 and over”. Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers. Reviews, case reports, studies not in English and studies for which no full text was available were excluded. A total of 26 papers were included in the final analysis.
Recent Findings
Genomic markers of bipolar disorder in older adults highlighted the implication of serotonin metabolism, while the expression of genes involved in angiogenesis was dysregulated. Peripheral blood markers were mainly related with low grade inflammation, axonal damage, endothelial dysfunction, and the dysregulation of the HPA axis. Neuroanatomical markers reflected a dysfunction of the frontal cortex, a loss of neurones in the anterior cingulate cortex and a reduction of the hippocampal volume (in patients older than 50 years old). While not necessarily limited to older adults, some of them may be useful for differential diagnosis (neurofilaments), disease staging (homocysteine, BDNF) and the monitoring of treatment outcomes (matrix metalloproteinases).
Summary
Our review provides a comprehensive overview of the current evidence on biomarkers for bipolar disorder in the older adults. The identification of biomarkers may aid in the diagnosis, treatment selection, and monitoring of bipolar disorder in older adults, ultimately leading to improved outcomes for this population. Further research is needed to validate and further explore the potential clinical utility of biomarkers in this population. |
doi_str_mv | 10.1007/s11920-024-01483-7 |
format | Article |
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Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and “Aged, 80 and over”. Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers. Reviews, case reports, studies not in English and studies for which no full text was available were excluded. A total of 26 papers were included in the final analysis.
Recent Findings
Genomic markers of bipolar disorder in older adults highlighted the implication of serotonin metabolism, while the expression of genes involved in angiogenesis was dysregulated. Peripheral blood markers were mainly related with low grade inflammation, axonal damage, endothelial dysfunction, and the dysregulation of the HPA axis. Neuroanatomical markers reflected a dysfunction of the frontal cortex, a loss of neurones in the anterior cingulate cortex and a reduction of the hippocampal volume (in patients older than 50 years old). While not necessarily limited to older adults, some of them may be useful for differential diagnosis (neurofilaments), disease staging (homocysteine, BDNF) and the monitoring of treatment outcomes (matrix metalloproteinases).
Summary
Our review provides a comprehensive overview of the current evidence on biomarkers for bipolar disorder in the older adults. The identification of biomarkers may aid in the diagnosis, treatment selection, and monitoring of bipolar disorder in older adults, ultimately leading to improved outcomes for this population. Further research is needed to validate and further explore the potential clinical utility of biomarkers in this population.</description><identifier>ISSN: 1523-3812</identifier><identifier>EISSN: 1535-1645</identifier><identifier>DOI: 10.1007/s11920-024-01483-7</identifier><identifier>PMID: 38470559</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers ; Bipolar Disorder ; Humans ; Hypothalamo-Hypophyseal System ; Inflammation ; Life Sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Older people ; Pituitary-Adrenal System ; Psychiatry ; Systematic review ; Topical Collection on Mood Disorders</subject><ispartof>Current psychiatry reports, 2024-03, Vol.26 (3), p.78-103</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a940ccc060941188dffc2858c8378683c0a080341ea4dc1f80a06a2593da8ddf3</citedby><cites>FETCH-LOGICAL-c409t-a940ccc060941188dffc2858c8378683c0a080341ea4dc1f80a06a2593da8ddf3</cites><orcidid>0000-0002-6519-8586 ; 0000-0002-9142-1278 ; 0000-0003-0618-0690 ; 0000-0002-6963-6555 ; 0009-0009-3741-7508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11920-024-01483-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11920-024-01483-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38470559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04731183$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chancel, R.</creatorcontrib><creatorcontrib>Lopez-Castroman, J.</creatorcontrib><creatorcontrib>Baca-Garcia, E.</creatorcontrib><creatorcontrib>Mateos Alvarez, R.</creatorcontrib><creatorcontrib>Courtet, Ph</creatorcontrib><creatorcontrib>Conejero, I.</creatorcontrib><title>Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review</title><title>Current psychiatry reports</title><addtitle>Curr Psychiatry Rep</addtitle><addtitle>Curr Psychiatry Rep</addtitle><description>Purpose of Review
Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and “Aged, 80 and over”. Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers. Reviews, case reports, studies not in English and studies for which no full text was available were excluded. A total of 26 papers were included in the final analysis.
Recent Findings
Genomic markers of bipolar disorder in older adults highlighted the implication of serotonin metabolism, while the expression of genes involved in angiogenesis was dysregulated. Peripheral blood markers were mainly related with low grade inflammation, axonal damage, endothelial dysfunction, and the dysregulation of the HPA axis. Neuroanatomical markers reflected a dysfunction of the frontal cortex, a loss of neurones in the anterior cingulate cortex and a reduction of the hippocampal volume (in patients older than 50 years old). While not necessarily limited to older adults, some of them may be useful for differential diagnosis (neurofilaments), disease staging (homocysteine, BDNF) and the monitoring of treatment outcomes (matrix metalloproteinases).
Summary
Our review provides a comprehensive overview of the current evidence on biomarkers for bipolar disorder in the older adults. The identification of biomarkers may aid in the diagnosis, treatment selection, and monitoring of bipolar disorder in older adults, ultimately leading to improved outcomes for this population. Further research is needed to validate and further explore the potential clinical utility of biomarkers in this population.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Bipolar Disorder</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System</subject><subject>Inflammation</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Pituitary-Adrenal System</subject><subject>Psychiatry</subject><subject>Systematic review</subject><subject>Topical Collection on Mood Disorders</subject><issn>1523-3812</issn><issn>1535-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1DAURq0K1JbSP8ACWWJTFobrRxKH3UwfFCkSCOjacu0bcMnEUzszqP--nqYUiQUrv879rq8OIa84vOMAzfvMeSuAgVAMuNKSNXvkkFeyYrxW1bPdXkgmNRcH5EXONwACQIt9ciC1aqCq2kPyZRniyqZfmDKNPV2GdRxsomchx-Qx0TDSzk5Iu9DjB7oY6fk2eBwdsqXN6Om3uzzhyk7B0a-4Dfj7JXne2yHj8eN6RK4uzr-fXrLu88dPp4uOOQXtxGyrwDkHNbSKc6193zuhK-20bHStpQMLGqTiaJV3vNflXFtRtdJb7X0vj8jbOfenHcw6hTLEnYk2mMtFZ3Z3oBpZkuWWF_ZkZtcp3m4wT2YVssNhsCPGTTairerSs4G2oG_-QW_iJo1lkkLVUgsl6qZQYqZcijkn7J9-wMHs3JjZjSluzIMbsyt6_Ri9uV6hfyr5I6MAcgZyeRp_YPrb-z-x9964llA</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Chancel, R.</creator><creator>Lopez-Castroman, J.</creator><creator>Baca-Garcia, E.</creator><creator>Mateos Alvarez, R.</creator><creator>Courtet, Ph</creator><creator>Conejero, I.</creator><general>Springer US</general><general>Springer Nature B.V</general><general>Current Medicine Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0002-9142-1278</orcidid><orcidid>https://orcid.org/0000-0003-0618-0690</orcidid><orcidid>https://orcid.org/0000-0002-6963-6555</orcidid><orcidid>https://orcid.org/0009-0009-3741-7508</orcidid></search><sort><creationdate>20240301</creationdate><title>Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review</title><author>Chancel, R. ; Lopez-Castroman, J. ; Baca-Garcia, E. ; Mateos Alvarez, R. ; Courtet, Ph ; Conejero, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a940ccc060941188dffc2858c8378683c0a080341ea4dc1f80a06a2593da8ddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Bipolar Disorder</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System</topic><topic>Inflammation</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Pituitary-Adrenal System</topic><topic>Psychiatry</topic><topic>Systematic review</topic><topic>Topical Collection on Mood Disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chancel, R.</creatorcontrib><creatorcontrib>Lopez-Castroman, J.</creatorcontrib><creatorcontrib>Baca-Garcia, E.</creatorcontrib><creatorcontrib>Mateos Alvarez, R.</creatorcontrib><creatorcontrib>Courtet, Ph</creatorcontrib><creatorcontrib>Conejero, I.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Current psychiatry reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chancel, R.</au><au>Lopez-Castroman, J.</au><au>Baca-Garcia, E.</au><au>Mateos Alvarez, R.</au><au>Courtet, Ph</au><au>Conejero, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review</atitle><jtitle>Current psychiatry reports</jtitle><stitle>Curr Psychiatry Rep</stitle><addtitle>Curr Psychiatry Rep</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>26</volume><issue>3</issue><spage>78</spage><epage>103</epage><pages>78-103</pages><issn>1523-3812</issn><eissn>1535-1645</eissn><abstract>Purpose of Review
Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and “Aged, 80 and over”. Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers. Reviews, case reports, studies not in English and studies for which no full text was available were excluded. A total of 26 papers were included in the final analysis.
Recent Findings
Genomic markers of bipolar disorder in older adults highlighted the implication of serotonin metabolism, while the expression of genes involved in angiogenesis was dysregulated. Peripheral blood markers were mainly related with low grade inflammation, axonal damage, endothelial dysfunction, and the dysregulation of the HPA axis. Neuroanatomical markers reflected a dysfunction of the frontal cortex, a loss of neurones in the anterior cingulate cortex and a reduction of the hippocampal volume (in patients older than 50 years old). While not necessarily limited to older adults, some of them may be useful for differential diagnosis (neurofilaments), disease staging (homocysteine, BDNF) and the monitoring of treatment outcomes (matrix metalloproteinases).
Summary
Our review provides a comprehensive overview of the current evidence on biomarkers for bipolar disorder in the older adults. The identification of biomarkers may aid in the diagnosis, treatment selection, and monitoring of bipolar disorder in older adults, ultimately leading to improved outcomes for this population. Further research is needed to validate and further explore the potential clinical utility of biomarkers in this population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38470559</pmid><doi>10.1007/s11920-024-01483-7</doi><tpages>26</tpages><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0002-9142-1278</orcidid><orcidid>https://orcid.org/0000-0003-0618-0690</orcidid><orcidid>https://orcid.org/0000-0002-6963-6555</orcidid><orcidid>https://orcid.org/0009-0009-3741-7508</orcidid></addata></record> |
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subjects | Aged Aged, 80 and over Biomarkers Bipolar Disorder Humans Hypothalamo-Hypophyseal System Inflammation Life Sciences Medicine Medicine & Public Health Middle Aged Older people Pituitary-Adrenal System Psychiatry Systematic review Topical Collection on Mood Disorders |
title | Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review |
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