Dosimetric feasibility study (“proof of concept”) of refractory ventricular tachycardia radioablation using proton minibeams

Preclinical data demonstrated that the use of proton minibeam radiotherapy reduces the risk of toxicity in healthy tissue. Ventricular tachycardia radioablation is an area under clinical investigation in proton beam therapy. We sought to simulate a ventricular tachycardia radioablation with proton minibeams and to demonstrate that it was possible to obtain a homogeneous coverage of an arrhythmogenic cardiac zone with this technique. An arrhythmogenic target volume was defined on the simulation CT scan of a patient, localized in the lateral wall of the left ventricle. A dose of 25Gy was planned to be delivered by proton minibeam radiotherapy, simulated using a Monte Carlo code (TOPAS v.3.7) with a collimator of 19 0.4 mm-wide slits spaced 3mm apart. The main objective of the study was to obtain a plan ensuring at least 93% of the prescription dose in 93% of the planning target volume without exceeding 110% of the prescribed dose in the planning target volume. The average dose in the planning treatment volume in proton minibeam radiotherapy was 25.12Gy. The percentage of the planning target volume receiving 93% (V93%), 110% (V110%), and 95% (V95%) of the prescribed dose was 94.25%, 0%, and 92.6% respectively. The lateral penumbra was 6.6mm. The mean value of the peak-to-valley-dose ratio in the planning target volume was 1.06. The mean heart dose was 2.54Gy versus 5.95Gy with stereotactic photon beam irradiation. This proof-of-concept study shows that proton minibeam radiotherapy can achieve a homogeneous coverage of an arrhythmogenic cardiac zone, reducing the dose at the normal tissues. This technique, ensuring could theoretically reduce the risk of late pulmonary and breast fibrosis, as well as cardiac toxicity as seen in previous biological studies in proton minibeam radiotherapy. Les données précliniques ont démontré que l’utilisation de la radiothérapie par minifaisceaux de protons réduit le risque de toxicité pour les tissus sains. La radioablation de la tachycardie ventriculaire est un domaine faisant l’objet d’investigations cliniques en thérapie par faisceaux de protons. Nous avons cherché à simuler une radioablation de la tachycardie ventriculaire par minifaisceaux de protons et à démontrer qu’il était possible d’obtenir une couverture homogène. Un volume cible arythmogène a été défini sur la scanographie de simulation d’un patient, localisé dans la paroi latérale du ventricule gauche. Une dose de 25Gy devait être délivrée par minifaisceaux de pro