Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases
To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases. In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and pati...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2025-01, Vol.63 (2), p.338-345 |
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| creator | Kahouadji, Samy Pereira, Bruno Sapin, Vincent Valentin, Audrey Bonnet, Agathe Dionet, Elsa Durif, Julie Lahaye, Clément Boisgard, Stéphane Moisset, Xavier Bouvier, Damien |
| description | To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases.
In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7).
In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aβ40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p |
| doi_str_mv | 10.1515/cclm-2024-0729 |
| format | Article |
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In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7).
In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aβ40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p<0.001) were significantly increased with neurodegeneration when compared to controls, with only p-tau217 significant in the multivariate analysis (p<0.001). Multivariate regression analysis accounting for age highlighted a significant increase of p-tau217 (p<0.001) in the AD subgroup. NFL was significantly increased in the non-AD patients (p<0.001), and in the parkinsonian syndromes subgroup (p=0.016) when compared to negative controls. Serum p-tau181 and p-tau217 were significantly correlated with CSF p-tau181 (Spearman's coefficients of 0.43 and 0.48 respectively, n=40). Areas under the ROC curves for the identification of patients with neurodegenerative diseases were 0.62 (0.54-0.70) for NFL, 0.62 (0.54-0.71) for T-tau, 0.83 (0.76-0.89) for p-tau217, and 0.66 (0.58-0.74) for Aβ40.
Serum biomarkers can help identify patients with neurodegenerative disease and may be a valuable tool for care and orientation. Phosphorylated tau p-tau217 is a promising blood biomarker for AD and NFL for other etiologies.</description><identifier>ISSN: 1434-6621</identifier><identifier>ISSN: 1437-4331</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2024-0729</identifier><identifier>PMID: 39297506</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Alzheimer ; Alzheimer's disease ; Basal ganglia ; Biomarkers ; Central nervous system diseases ; Cerebrospinal fluid ; Disorders ; Etiology ; Life Sciences ; Movement disorders ; Multivariate analysis ; Neurodegeneration ; Neurodegenerative diseases ; neurofilament light (NFL) ; Neurology ; Neurons and Cognition ; Observational studies ; Orthopedics ; p-tau181 ; p-tau217 ; Regression analysis ; serum ; Subgroups ; T-tau ; Tau protein</subject><ispartof>Clinical chemistry and laboratory medicine, 2025-01, Vol.63 (2), p.338-345</ispartof><rights>2024 Walter de Gruyter GmbH, Berlin/Boston.</rights><rights>2024 Walter de Gruyter GmbH, Berlin/Boston</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c295t-1b20ba569bfb5f37b09d93f346cd02504b085022a39d6bae9cbe2ec2e1662e863</cites><orcidid>0000-0002-5918-1315 ; 0000-0002-7452-315X ; 0000-0002-8799-0750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2024-0729/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2024-0729/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,66503,68287</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39297506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04721386$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahouadji, Samy</creatorcontrib><creatorcontrib>Pereira, Bruno</creatorcontrib><creatorcontrib>Sapin, Vincent</creatorcontrib><creatorcontrib>Valentin, Audrey</creatorcontrib><creatorcontrib>Bonnet, Agathe</creatorcontrib><creatorcontrib>Dionet, Elsa</creatorcontrib><creatorcontrib>Durif, Julie</creatorcontrib><creatorcontrib>Lahaye, Clément</creatorcontrib><creatorcontrib>Boisgard, Stéphane</creatorcontrib><creatorcontrib>Moisset, Xavier</creatorcontrib><creatorcontrib>Bouvier, Damien</creatorcontrib><title>Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases.
In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7).
In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aβ40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p<0.001) were significantly increased with neurodegeneration when compared to controls, with only p-tau217 significant in the multivariate analysis (p<0.001). Multivariate regression analysis accounting for age highlighted a significant increase of p-tau217 (p<0.001) in the AD subgroup. NFL was significantly increased in the non-AD patients (p<0.001), and in the parkinsonian syndromes subgroup (p=0.016) when compared to negative controls. Serum p-tau181 and p-tau217 were significantly correlated with CSF p-tau181 (Spearman's coefficients of 0.43 and 0.48 respectively, n=40). Areas under the ROC curves for the identification of patients with neurodegenerative diseases were 0.62 (0.54-0.70) for NFL, 0.62 (0.54-0.71) for T-tau, 0.83 (0.76-0.89) for p-tau217, and 0.66 (0.58-0.74) for Aβ40.
Serum biomarkers can help identify patients with neurodegenerative disease and may be a valuable tool for care and orientation. Phosphorylated tau p-tau217 is a promising blood biomarker for AD and NFL for other etiologies.</description><subject>Alzheimer</subject><subject>Alzheimer's disease</subject><subject>Basal ganglia</subject><subject>Biomarkers</subject><subject>Central nervous system diseases</subject><subject>Cerebrospinal fluid</subject><subject>Disorders</subject><subject>Etiology</subject><subject>Life Sciences</subject><subject>Movement disorders</subject><subject>Multivariate analysis</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>neurofilament light (NFL)</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Observational studies</subject><subject>Orthopedics</subject><subject>p-tau181</subject><subject>p-tau217</subject><subject>Regression analysis</subject><subject>serum</subject><subject>Subgroups</subject><subject>T-tau</subject><subject>Tau protein</subject><issn>1434-6621</issn><issn>1437-4331</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNptkc1u1DAUhS0Eoj-wZYkssaHSpPjfscRmVLUUaQSbsrbs5KZNlcSDnQzqa_EgPBN2ZygSYnWP7M_n3uuD0BtKzqmk8kPTDGPFCBMV0cw8Q8dUcF0JzunzRy0qpRg9Qicp3RNCpRT6JTrihhktiTpG6XLnhsXNfZhw6HCCuIz4y9VmhW-q2S0rvC2F1vSgGNUrvP71UxDspvZRMdyFiOc7wG3vbqeQ-lSsJlhiaOEWJojZf1euE7gE6RV60bkhwetDPUXfri5vLq6rzddPny_Wm6phRs4V9Yx4J5XxnZcd156Y1vCOC9W0hEkiPKklYcxx0yrvwDQeGDQMaF4ZasVP0dne984Ndhv70cUHG1xvr9cbW86I0IzyWu1oZt_v2W0M3xdIsx371MAwuAnCkiynpM6kojqj7_5B78MSp7xJpoQxnGlSmp_vqSaGlCJ0TxNQYkt0tkRnS3S2RJcfvD3YLn6E9gn_k1UGPu6BH26YIeavjctDFn_b_99ZccZ5zX8D4VClvw</recordid><startdate>20250129</startdate><enddate>20250129</enddate><creator>Kahouadji, Samy</creator><creator>Pereira, Bruno</creator><creator>Sapin, Vincent</creator><creator>Valentin, Audrey</creator><creator>Bonnet, Agathe</creator><creator>Dionet, Elsa</creator><creator>Durif, Julie</creator><creator>Lahaye, Clément</creator><creator>Boisgard, Stéphane</creator><creator>Moisset, Xavier</creator><creator>Bouvier, Damien</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5918-1315</orcidid><orcidid>https://orcid.org/0000-0002-7452-315X</orcidid><orcidid>https://orcid.org/0000-0002-8799-0750</orcidid></search><sort><creationdate>20250129</creationdate><title>Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases</title><author>Kahouadji, Samy ; Pereira, Bruno ; Sapin, Vincent ; Valentin, Audrey ; Bonnet, Agathe ; Dionet, Elsa ; Durif, Julie ; Lahaye, Clément ; Boisgard, Stéphane ; Moisset, Xavier ; Bouvier, Damien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-1b20ba569bfb5f37b09d93f346cd02504b085022a39d6bae9cbe2ec2e1662e863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Alzheimer</topic><topic>Alzheimer's disease</topic><topic>Basal ganglia</topic><topic>Biomarkers</topic><topic>Central nervous system diseases</topic><topic>Cerebrospinal fluid</topic><topic>Disorders</topic><topic>Etiology</topic><topic>Life Sciences</topic><topic>Movement disorders</topic><topic>Multivariate analysis</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>neurofilament light (NFL)</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Observational studies</topic><topic>Orthopedics</topic><topic>p-tau181</topic><topic>p-tau217</topic><topic>Regression analysis</topic><topic>serum</topic><topic>Subgroups</topic><topic>T-tau</topic><topic>Tau protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahouadji, Samy</creatorcontrib><creatorcontrib>Pereira, Bruno</creatorcontrib><creatorcontrib>Sapin, Vincent</creatorcontrib><creatorcontrib>Valentin, Audrey</creatorcontrib><creatorcontrib>Bonnet, Agathe</creatorcontrib><creatorcontrib>Dionet, Elsa</creatorcontrib><creatorcontrib>Durif, Julie</creatorcontrib><creatorcontrib>Lahaye, Clément</creatorcontrib><creatorcontrib>Boisgard, Stéphane</creatorcontrib><creatorcontrib>Moisset, Xavier</creatorcontrib><creatorcontrib>Bouvier, Damien</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahouadji, Samy</au><au>Pereira, Bruno</au><au>Sapin, Vincent</au><au>Valentin, Audrey</au><au>Bonnet, Agathe</au><au>Dionet, Elsa</au><au>Durif, Julie</au><au>Lahaye, Clément</au><au>Boisgard, Stéphane</au><au>Moisset, Xavier</au><au>Bouvier, Damien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2025-01-29</date><risdate>2025</risdate><volume>63</volume><issue>2</issue><spage>338</spage><epage>345</epage><pages>338-345</pages><issn>1434-6621</issn><issn>1437-4331</issn><eissn>1437-4331</eissn><abstract>To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases.
In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7).
In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aβ40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p<0.001) were significantly increased with neurodegeneration when compared to controls, with only p-tau217 significant in the multivariate analysis (p<0.001). Multivariate regression analysis accounting for age highlighted a significant increase of p-tau217 (p<0.001) in the AD subgroup. NFL was significantly increased in the non-AD patients (p<0.001), and in the parkinsonian syndromes subgroup (p=0.016) when compared to negative controls. Serum p-tau181 and p-tau217 were significantly correlated with CSF p-tau181 (Spearman's coefficients of 0.43 and 0.48 respectively, n=40). Areas under the ROC curves for the identification of patients with neurodegenerative diseases were 0.62 (0.54-0.70) for NFL, 0.62 (0.54-0.71) for T-tau, 0.83 (0.76-0.89) for p-tau217, and 0.66 (0.58-0.74) for Aβ40.
Serum biomarkers can help identify patients with neurodegenerative disease and may be a valuable tool for care and orientation. Phosphorylated tau p-tau217 is a promising blood biomarker for AD and NFL for other etiologies.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>39297506</pmid><doi>10.1515/cclm-2024-0729</doi><tpages>08</tpages><orcidid>https://orcid.org/0000-0002-5918-1315</orcidid><orcidid>https://orcid.org/0000-0002-7452-315X</orcidid><orcidid>https://orcid.org/0000-0002-8799-0750</orcidid></addata></record> |
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| ispartof | Clinical chemistry and laboratory medicine, 2025-01, Vol.63 (2), p.338-345 |
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| subjects | Alzheimer Alzheimer's disease Basal ganglia Biomarkers Central nervous system diseases Cerebrospinal fluid Disorders Etiology Life Sciences Movement disorders Multivariate analysis Neurodegeneration Neurodegenerative diseases neurofilament light (NFL) Neurology Neurons and Cognition Observational studies Orthopedics p-tau181 p-tau217 Regression analysis serum Subgroups T-tau Tau protein |
| title | Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases |
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