Evaluation of serum NFL, T-tau, p-tau181, p-tau217, Aβ40 and Aβ42 for the diagnosis of neurodegenerative diseases

To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases. In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and pati...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2025-01, Vol.63 (2), p.338-345
Hauptverfasser:	Kahouadji, Samy, Pereira, Bruno, Sapin, Vincent, Valentin, Audrey, Bonnet, Agathe, Dionet, Elsa, Durif, Julie, Lahaye, Clément, Boisgard, Stéphane, Moisset, Xavier, Bouvier, Damien
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Alzheimer's disease Basal ganglia Biomarkers Central nervous system diseases Cerebrospinal fluid Disorders Etiology Life Sciences Movement disorders Multivariate analysis Neurodegeneration Neurodegenerative diseases neurofilament light (NFL) Neurology Neurons and Cognition Observational studies Orthopedics p-tau181 p-tau217 Regression analysis serum Subgroups T-tau Tau protein
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Zusammenfassung:	To assess the variations and diagnostic performance of serum biomarkers of neurodegenerative diseases. In this monocentric prospective study, neurofilament light (NFL), T-tau, p-tau181, p-tau217, Aβ40, and Aβ42 were measured in serum collected from orthopedic patients (control group, n=114) and patients in the neurology department (n=69) previously diagnosed with Alzheimer's disease (AD, n=52), parkinsonian syndromes (n=10), and other etiologies of neurodegeneration (non-AD, n=7). In the control group, serum NFL, T-tau, p-tau181, p-tau217, and Aβ40 significantly increased with age, independently of sex. NFL (p=0.0078), p-tau217 (p
ISSN:	1434-6621 1437-4331 1437-4331
DOI:	10.1515/cclm-2024-0729