iMab antibody binds single-stranded cytosine-rich sequences and unfolds DNA i-motifs

iMab antibody binds single-stranded cytosine-rich sequences and unfolds DNA i-motifs

Abstract i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by stacking of hemi-protonated CH+·C base pairs in cytosine-rich DNA sequences, predominantly at pH 

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Veröffentlicht in:Nucleic acids research 2024-08, Vol.52 (14), p.8052-8062
Hauptverfasser: Boissieras, Joseph, Bonnet, Hugues, Susanto, Maria Fidelia, Gomez, Dennis, Defrancq, Eric, Granzhan, Anton, Dejeu, Jérôme
Format: Artikel
Sprache:eng
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Life Sciences
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Zusammenfassung:Abstract i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by stacking of hemi-protonated CH+·C base pairs in cytosine-rich DNA sequences, predominantly at pH 
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkae531