COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non‐severe recurrent wheeze (NSRW)/non‐severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between chil...

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Veröffentlicht in:	Pediatric allergy and immunology 2024-03, Vol.35 (3), p.e14112-n/a
Hauptverfasser:	Lejeune, Stéphanie, Bouazza, Naïm, Nicaise, Pascale Roland, Jolaine, Valérie, Roditis, Léa, Marguet, Christophe, Amat, Flore, Berger, Patrick, Fayon, Michael, Dubus, Jean‐Christophe, Valois, Sophie, Reix, Philippe, Pellan, Mathieu, Brouard, Jacques, Chiron, Raphael, Giovannini‐Chami, Lisa, Blic, Jacques, Deschildre, Antoine, Lezmi, Guillaume, Abou‐Taam, Rola, Le Bourgeois, Muriel, Hadchouel‐Duvergé, Alice, Drummond, David, Delacourt, Christophe, Alyanakian, Marie‐Alexandra, Chatennoud, Lucienne, Thumerelle, Caroline, Mordacq, Clémence, Badiu‐Decleyre, Irina, Bonnel, Cécile, Delbecque, Laure, Beghin, Laurent, Mingardi, Graziella, Tournegros, Caroline, Blanchon, Sylvain, Houdoin, Véronique, Wanin, Stéphanie, Lebras, Marie Noelle, Debelleix, Stéphane, Siao, Valérie, Servat, Marine, Simon, Guillaume, El Boustany, Patricia, Bosdure, Emmanuelle, Mazenq, Julie, Cabon, Isabelle, Ohlmann, Camille, Vrielynck, Stéphanie, Jubin, Virginie, Gomez, Sylvie‐Anne André, Gallois, Marie‐Christine Werck, Biermé, Priscille, Pin, Isabelle, Chollet‐Martin, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergies Allergology Asthma Children Cluster analysis Human health and pathology Immune response Immunoglobulin E Immunoglobulins Immunology Life Sciences Pediatrics preschool Preschool children Pulmonology and respiratory tract Respiratory diseases Santé publique et épidémiologie school‐age Sensitivity analysis sensitization severe asthma
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Zusammenfassung:	Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non‐severe recurrent wheeze (NSRW)/non‐severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA. Methods IgE to 112 components (c‐sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3–6 years) and 170 school‐age children (7–12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c‐sIgE. Results We observed c‐sIgE sensitization in 51% of preschool and 75% of school‐age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p
ISSN:	0905-6157 1399-3038
DOI:	10.1111/pai.14112