Monocytic Human Leukocyte Antigen DR Expression in Young Infants Undergoing Cardiopulmonary Bypass

Monocytic human leukocyte antigen DR (mHLA-DR) expression levels have been reported to be a marker of immunosuppression and a predictor of sepsis and mortality. There are, however, scant data regarding mHLA-DR monitoring in young infants after cardiopulmonary bypass. Our objectives were to investiga...

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Veröffentlicht in:	The Annals of thoracic surgery 2021-05, Vol.111 (5), p.1636-1642
Hauptverfasser:	Chenouard, Alexis, Rimbert, Marie, Joram, Nicolas, Braudeau, Cécile, Roquilly, Antoine, Bourgoin, Pierre, Asehnoune, Karim, Salabert, Nina, Vourc'h, Mickaël, Josien, Régis, Gras-Leguen, Christèle
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiopulmonary Bypass Cross Infection - blood Cross Infection - epidemiology Cross Infection - immunology Female Heart Defects, Congenital - surgery HLA-DR Antigens - biosynthesis HLA-DR Antigens - blood Humans Infant Infant, Newborn Life Sciences Male Monocytes - immunology Postoperative Complications - blood Postoperative Complications - epidemiology Postoperative Complications - immunology Prospective Studies
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Zusammenfassung:	Monocytic human leukocyte antigen DR (mHLA-DR) expression levels have been reported to be a marker of immunosuppression and a predictor of sepsis and mortality. There are, however, scant data regarding mHLA-DR monitoring in young infants after cardiopulmonary bypass. Our objectives were to investigate the kinetics of mHLA-DR expression and to determine whether mHLA-DR levels are associated with healthcare-associated infection (HAI) after cardiopulmonary bypass in young infants. mHLA-DR levels were analyzed by flow cytometry using a standardized method in 49 infants (
ISSN:	0003-4975 1552-6259
DOI:	10.1016/j.athoracsur.2020.05.071