$Tinzaparin, an alternative to subcutaneous unfractionated heparin, in patients with severe and end-stage renal impairment: a retrospective observational single-center study$

Tinzaparin, an alternative to subcutaneous unfractionated heparin, in patients with severe and end-stage renal impairment: a retrospective observational single-center study

Tinzaparin could be easier to manage than unfractionated heparin in patients with severe renal impairment. However, clinical and pharmacologic data regarding its use in such patients are lacking. The aims of this study were to determine, in patients with estimated glomerular filtration rate (eGFR) o...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2024-10, Vol.22 (10), p.2864-2872
Hauptverfasser:	Gouin-Thibault, Isabelle, Mansour, Alexandre, Caribotti, Charlène, Pierre-Jean, Morgane, Bouzille, Guillaume, Ballerie, Alice, Maucorps, Laure, Gueret, Pierre, Nédelec-Gac, Fabienne, Pontis, Adeline, Mahé, Guillaume, Vannier, Stéphane, Behar, Nathalie, Cardiet, Isabelle, Mismetti, Patrick, Frouget, Thierry, Delavenne, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulants - pharmacokinetics Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Fibrinolytic Agents - pharmacokinetics Glomerular Filtration Rate hemorrhage Hemorrhage - chemically induced Heparin - administration & dosage Heparin - adverse effects Heparin - pharmacokinetics Heparin, Low-Molecular-Weight - administration & dosage Heparin, Low-Molecular-Weight - pharmacokinetics Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Life Sciences low-molecular-weight heparin Male Middle Aged Monte Carlo Method pharmacokinetics renal insufficiency Retrospective Studies Thrombosis - blood Thrombosis - drug therapy Thrombosis - prevention & control tinzaparin Tinzaparin - administration & dosage Tinzaparin - pharmacokinetics Treatment Outcome
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Zusammenfassung:	Tinzaparin could be easier to manage than unfractionated heparin in patients with severe renal impairment. However, clinical and pharmacologic data regarding its use in such patients are lacking. The aims of this study were to determine, in patients with estimated glomerular filtration rate (eGFR) of
ISSN:	1538-7836 1538-7836
DOI:	10.1016/j.jtha.2024.07.006