Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis
We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-...
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| Veröffentlicht in: | Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2000-08, Vol.56 (8), p.1037-1039 |
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| container_end_page | 1039 |
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| container_issue | 8 |
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| container_title | Acta crystallographica. Section C, Crystal structure communications |
| container_volume | 56 |
| creator | KASSEM, T ROLLAND, V MARTINEZ, J ROLLAND, M |
| description | We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-hexahydro-3-(1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(3). A new optically pure chiral oxazinone auxiliary derived from (1R,2R, 5R)-2-hydroxypinan-3-one was used. |
| doi_str_mv | 10.1107/S010827010000740X |
| format | Article |
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Section C, Crystal structure communications</title><addtitle>Acta Crystallogr C</addtitle><description>We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-hexahydro-3-(1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(3). 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| identifier | ISSN: 0108-2701 |
| ispartof | Acta crystallographica. Section C, Crystal structure communications, 2000-08, Vol.56 (8), p.1037-1039 |
| issn | 0108-2701 1600-5759 |
| language | eng |
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| source | MEDLINE; Crystallography Journals Online; Access via Wiley Online Library |
| subjects | Chemical Sciences Condensed matter: structure, mechanical and thermal properties Cristallography Crystallography, X-Ray Exact sciences and technology Heterocyclic compounds Hydrogen Bonding Isoleucine - analogs & derivatives Isoleucine - chemical synthesis Isoleucine - chemistry Medicinal Chemistry Models, Molecular Molecular Conformation Organic chemistry Organic compounds Physics Plants, Medicinal - chemistry Stereoisomerism Structure of solids and liquids crystallography Structure of specific crystalline solids |
| title | Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis |
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