Two key chiral intermediates in a new 4-hydroxyisoleucine synthesis

We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-...

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Veröffentlicht in:	Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2000-08, Vol.56 (8), p.1037-1039
Hauptverfasser:	KASSEM, T, ROLLAND, V, MARTINEZ, J, ROLLAND, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Condensed matter: structure, mechanical and thermal properties Cristallography Crystallography, X-Ray Exact sciences and technology Heterocyclic compounds Hydrogen Bonding Isoleucine - analogs & derivatives Isoleucine - chemical synthesis Isoleucine - chemistry Medicinal Chemistry Models, Molecular Molecular Conformation Organic chemistry Organic compounds Physics Plants, Medicinal - chemistry Stereoisomerism Structure of solids and liquids crystallography Structure of specific crystalline solids
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Beschreibung
Zusammenfassung:	We present the crystal and molecular structure of two key compounds of a new synthesis strategy for isomers of natural (2S,3R, 4S)-4-hydroxyisoleucines, 2,3,5,6,7, 8-hexahydro-3-(1-hydroxy-1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(4), and 2,3,5,6,7, 8-hexahydro-3-(1-methyl-2-oxopropyl)-6,8-methano-7,7, 8a-trimethyl-5H-1,4-benzoxazin-2-one, C(16)H(23)NO(3). A new optically pure chiral oxazinone auxiliary derived from (1R,2R, 5R)-2-hydroxypinan-3-one was used.
ISSN:	0108-2701 1600-5759
DOI:	10.1107/S010827010000740X