Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Enantiomerically pure ( S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp. Graphic

Bibliographische Detailangaben

Veröffentlicht in:	Tetrahedron: asymmetry 2000-12, Vol.11 (23), p.4719-4724
Hauptverfasser:	Rolland-Fulcrand, Valérie, Haroune, Nicolas, Roumestant, Maire Louise, Martinez, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Medicinal Chemistry Organic chemistry Other
Online-Zugang:	Volltext
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