Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Enantiomerically pure ( S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp. Graphic

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Veröffentlicht in:Tetrahedron: asymmetry 2000-12, Vol.11 (23), p.4719-4724
Hauptverfasser: Rolland-Fulcrand, Valérie, Haroune, Nicolas, Roumestant, Maire Louise, Martinez, Jean
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Medicinal Chemistry
Organic chemistry
Other
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Zusammenfassung:Enantiomerically pure ( S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp. Graphic
ISSN:0957-4166
1362-511X
0957-4166
DOI:10.1016/S0957-4166(00)00463-8