Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives
Enantiomerically pure ( S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp. Graphic
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| Veröffentlicht in: | Tetrahedron: asymmetry 2000-12, Vol.11 (23), p.4719-4724 |
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| container_issue | 23 |
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| container_title | Tetrahedron: asymmetry |
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| creator | Rolland-Fulcrand, Valérie Haroune, Nicolas Roumestant, Maire Louise Martinez, Jean |
| description | Enantiomerically pure (
S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from
Aspergillus sp.
Graphic |
| doi_str_mv | 10.1016/S0957-4166(00)00463-8 |
| format | Article |
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Aspergillus sp.
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| subjects | Chemical Sciences Medicinal Chemistry Organic chemistry Other |
| title | Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives |
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