New biocatalysts for peptide synthesis :Gels of copolymerized acrylic derivatives of α-chymotrypsin and polyoxyethylene

Copolymers of acrylated derivatives of α-chymotrypsin and polyethylene glycol (PEG*) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent. AcTyrLeuNH 2 is quantitatively obtained even after a dozen of cycles.

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Veröffentlicht in:Tetrahedron 1990, Vol.46 (11), p.3909-3920
Hauptverfasser: Fulcrand, Valérie, Jacquier, Robert, Lazaro, René, Viallefont, Philippe
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container_end_page 3920
container_issue 11
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container_title Tetrahedron
container_volume 46
creator Fulcrand, Valérie
Jacquier, Robert
Lazaro, René
Viallefont, Philippe
description Copolymers of acrylated derivatives of α-chymotrypsin and polyethylene glycol (PEG*) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent. AcTyrLeuNH 2 is quantitatively obtained even after a dozen of cycles.
doi_str_mv 10.1016/S0040-4020(01)90526-5
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subjects Catalysis
Chemical Sciences
Polymers
title New biocatalysts for peptide synthesis :Gels of copolymerized acrylic derivatives of α-chymotrypsin and polyoxyethylene
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