New biocatalysts for peptide synthesis :Gels of copolymerized acrylic derivatives of α-chymotrypsin and polyoxyethylene

New biocatalysts for peptide synthesis :Gels of copolymerized acrylic derivatives of α-chymotrypsin and polyoxyethylene

Copolymers of acrylated derivatives of α-chymotrypsin and polyethylene glycol (PEG*) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent. AcTyrLeuNH 2 is quantitatively obtained even after a dozen of cycles.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron 1990, Vol.46 (11), p.3909-3920
Hauptverfasser: Fulcrand, Valérie, Jacquier, Robert, Lazaro, René, Viallefont, Philippe
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemical Sciences
Polymers
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Zusammenfassung:Copolymers of acrylated derivatives of α-chymotrypsin and polyethylene glycol (PEG*) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent. AcTyrLeuNH 2 is quantitatively obtained even after a dozen of cycles.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)90526-5