Sub 20 nm Upconversion Photosensitizers for Near‐Infrared Photodynamic Theranostics

Sub 20 nm Upconversion Photosensitizers for Near‐Infrared Photodynamic Theranostics

Efficient type II photodynamic therapy (PDT) requires stable and biocompatible photosensitizers (PS) that present low dark cytotoxicity, are photo‐excitable in deep tissue regions, and can efficiently penetrate and kill cells via in situ singlet oxygen production. Here, heavy‐metal‐free organic PS a...

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Veröffentlicht in:Advanced functional materials 2025-01, Vol.35 (1), p.n/a
Hauptverfasser: Nsubuga, Anne, Morice, Korentin, Fayad, Nour, Pini, Federico, Josserand, Véronique, Le Guével, Xavier, Alhabi, Abdallah, Henry, Maxime, Puchán Sánchez, Dario, Plassais, Nathan, Josse, Pierre, Boixel, Julien, Blanchard, Philippe, Cabanetos, Clément, Hildebrandt, Niko
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Cell death
Chemical Sciences
dibenzothioxanthene imide
Energy transfer
FRET
imaging
In vivo methods and tests
Irradiance
Material chemistry
nanoparticles
Near infrared radiation
Oxygen production
PDT
Precision medicine
Singlet oxygen
thiochromenocarbazole imide
Upconversion
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Beschreibung
Zusammenfassung:Efficient type II photodynamic therapy (PDT) requires stable and biocompatible photosensitizers (PS) that present low dark cytotoxicity, are photo‐excitable in deep tissue regions, and can efficiently penetrate and kill cells via in situ singlet oxygen production. Here, heavy‐metal‐free organic PS are combined with near‐infrared (NIR)‐excitable small (
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202410077