Multifunctional host-defense peptides isolated from skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae)

Five host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) and...

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Veröffentlicht in:	Biochimie 2024-08, Vol.223, p.23-30
Hauptverfasser:	Conlon, J. Michael, Sridhar, Ananyaa, Khan, Dawood, Cunning, Taylor S., Delaney, Jack J., Taggart, Megan G., Ternan, Nigel G., Leprince, Jérôme, Coquet, Laurent, Jouenne, Thierry, Attoub, Samir, Mechkarska, Milena
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibia Animal biology Anti-cancer Anti-diabetic Antimicrobial Chemical Sciences Cytotoxicity Insulinotropic Life Sciences Medicinal Chemistry Type 2 diabetes Vertebrate Zoology
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Zusammenfassung:	Five host-defense peptides (figainin 2PL, hylin PL, raniseptin PL, plasticin PL, and peptide YL) were isolated from norepinephrine-stimulated skin secretions of the banana tree dwelling frog Boana platanera (Hylidae; Hylinae) collected in Trinidad. Raniseptin PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) and figainin 2PL (FLGTVLKLGKAIAKTVVPMLTNAMQPKQ. NH2) showed potent and rapid bactericidal activity against a range of clinically relevant Gram-positive and Gram-negative ESKAPE + pathogens and Clostridioides difficile. The peptides also showed potent cytotoxic activity (LC50 values
ISSN:	0300-9084 1638-6183 1638-6183
DOI:	10.1016/j.biochi.2024.03.012