Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma

A randomized trial comparing the CD19-specific CAR T-cell therapy tisagenlecleucel with salvage chemotherapy followed by high-dose therapy and autologous hematopoietic stem-cell transplantation in patients with refractory or early relapsed aggressive B-cell lymphoma did not show a longer event-free...

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Veröffentlicht in:	The New England journal of medicine 2022-02, Vol.386 (7), p.629-639
Hauptverfasser:	Bishop, Michael R, Dickinson, Michael, Purtill, Duncan, Barba, Pere, Santoro, Armando, Hamad, Nada, Kato, Koji, Sureda, Anna, Greil, Richard, Thieblemont, Catherine, Morschhauser, Franck, Janz, Martin, Flinn, Ian, Rabitsch, Werner, Kwong, Yok-Lam, Kersten, Marie J, Minnema, Monique C, Holte, Harald, Chan, Esther H.L, Martinez-Lopez, Joaquin, Müller, Antonia M.S, Maziarz, Richard T, McGuirk, Joseph P, Bachy, Emmanuel, Le Gouill, Steven, Dreyling, Martin, Harigae, Hideo, Bond, David, Andreadis, Charalambos, McSweeney, Peter, Kharfan-Dabaja, Mohamed, Newsome, Simon, Degtyarev, Evgeny, Awasthi, Rakesh, del Corral, Christopher, Andreola, Giovanna, Masood, Aisha, Schuster, Stephen J, Jäger, Ulrich, Borchmann, Peter, Westin, Jason R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autografts B-cell lymphoma Bone marrow Bone Marrow Transplantation CD19 antigen Cell therapy Chemotherapy Chimeric antigen receptors Combined Modality Therapy Female Genetics Genetics General Hematology Hematopoietic Stem Cell Transplantation Humans Immunotherapy, Adoptive Leukapheresis Leukemia Life Sciences Lymphocytes B Lymphocytes T Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - therapy Male Medical prognosis Middle Aged Non-Hodgkin's lymphoma Oncology Patients Progression-Free Survival Receptors, Antigen, T-Cell - therapeutic use Receptors, Chimeric Antigen - antagonists & inhibitors Salvage Therapy Severe acute respiratory syndrome coronavirus 2 Stem cell transplantation Tomography Transplantation, Autologous Treatments in Oncology
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Beschreibung
Zusammenfassung:	A randomized trial comparing the CD19-specific CAR T-cell therapy tisagenlecleucel with salvage chemotherapy followed by high-dose therapy and autologous hematopoietic stem-cell transplantation in patients with refractory or early relapsed aggressive B-cell lymphoma did not show a longer event-free survival with CAR T cells.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2116596