Sequences and predicted structures of chimpanzee STRL33 (Bonzo) and gpr15 (BOB)

The Seven-Transmembrane Receptors STRL33 and gpr15 have been shown to be coreceptors for many SIV isolates. They can also be used as coreceptors by some HIV isolates. The STRL33 and gpr15 sequences of human, African green monkey, and pigtail macaque have been reported, as has the gpr15 sequence of rhesus macaque. Chimpanzees (Pan troglodytes) are, however, one of the only primates to be infectable with human immunodeficiency virus type 1 (HIV-1). They are by far the main animal model for the study of HIV-1 infection. We therefore cloned and sequenced chimpanzee STRL33 and gpr15.