Two alleles for rhesus macaque GPR15 (BOB)

CHEMOKINE RECEPTORS are used for fusion by primate immunodeficiency viruses. CXCR4 and CCR5 are the two main coreceptors for HIV: they are used by lymphotropic and macrophage-tropic strains of viruses, respectively. Many other chemokine receptors have been described to be involved in fusion, at leas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	AIDS research and human retroviruses 1999-07, Vol.15 (10), p.945-947
Hauptverfasser:	PRETET, J.-L, BRUSSEL, A, GUILLET, J.-G, BUTOR, C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Alleles Amino Acid Sequence Animals Bacterial Proteins - genetics Base Sequence Biological and medical sciences DNA, Complementary Experimental viral diseases and models Fundamental and applied biological sciences. Psychology Genes. Genome Human immunodeficiency virus Humans Infectious diseases Life Sciences Macaca mulatta Macaca rhesus Male Medical sciences Molecular and cellular biology Molecular genetics Molecular Sequence Data Sigma Factor Simian immunodeficiency virus Transcription Factors Viral diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	CHEMOKINE RECEPTORS are used for fusion by primate immunodeficiency viruses. CXCR4 and CCR5 are the two main coreceptors for HIV: they are used by lymphotropic and macrophage-tropic strains of viruses, respectively. Many other chemokine receptors have been described to be involved in fusion, at least in vitro. One of these, GPR15 (also known as BOB), is particularly efficient for fusion of SIV strains. We show the existence of two alleles for gpr15 in rhesus macaques. The two alleles are well represented in our colony, as two randomly selected animals were heterozygotes. The existence of two or more alleles has been described for other chemokine receptors.
ISSN:	0889-2229 1931-8405
DOI:	10.1089/088922299310665