Effects of anabolic/androgenic steroids on regenerating skeletal muscles in the rat

We have examined the effect of male sexual hormones on the regeneration of skeletal muscles. Degeneration/regeneration of the left soleus and extensor digitorum longus muscles (EDL) of Wistar male rats was induced by an injection of snake venom (2 μg, Notechis scutatus scutatus). During the muscle r...

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Veröffentlicht in:	Acta physiologica Scandinavica 1999-06, Vol.166 (2), p.105-110
Hauptverfasser:	Ferry, Noirez, Page, C. Le, Salah, I. Ben, Daegelen, Rieu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anabolic Agents - pharmacology Animals Biological and medical sciences Drug intoxications. Doping Elapid Venoms - toxicity Fundamental and applied biological sciences. Psychology Life Sciences Male male sexual hormone Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - pathology Muscle, Skeletal - physiology myogenesis myosin heavy chain mRNA and protein Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism nandrolone Nandrolone - pharmacology Orchiectomy Pharmacology. Drug treatments Physical Conditioning, Animal Rats Rats, Wistar Regeneration - drug effects RNA - biosynthesis skeletal muscle regeneration Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	We have examined the effect of male sexual hormones on the regeneration of skeletal muscles. Degeneration/regeneration of the left soleus and extensor digitorum longus muscles (EDL) of Wistar male rats was induced by an injection of snake venom (2 μg, Notechis scutatus scutatus). During the muscle regeneration (25 days), rats were treated with either oil (CON), nandrolone (NAN), NAN combined with exercise (NAN + EXE) or were castrated (CAS). Muscle growth and myosin heavy chain (MyHC) isoform content of regenerating muscles were studied. Castration altered the concentrations of MyHC in venom‐treated EDL (P
ISSN:	0001-6772 1365-201X
DOI:	10.1046/j.1365-201x.1999.00549.x