A quantitative synthesis of β-carboxylated thiolophosphates via a Michael reaction
Reactions of O, O′-dialkylthiophosphoric acids with acrylates provide a direct synthetic route to β-carboxylated thiolophosphates. This Michael addition, without solvent, is quantitative at 90°C in 1 h for the 2/1 thiophosphoric acid/acrylate ratio. Moreover, this excess of thiophosphoric acid can b...
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| Veröffentlicht in: | Tetrahedron letters 2003-08, Vol.44 (33), p.6273-6276 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Reactions of
O,
O′-dialkylthiophosphoric acids with acrylates provide a direct synthetic route to β-carboxylated thiolophosphates. This Michael addition, without solvent, is quantitative at 90°C in 1 h for the 2/1 thiophosphoric acid/acrylate ratio. Moreover, this excess of thiophosphoric acid can be reused for further reactions.
β-Carboxylated thiolophosphates are synthesized quantitatively via a Michael reaction between two equivalents of
O,
O′-dialkylthiophosphate acid and acrylate compounds. |
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| ISSN: | 0040-4039 1873-3581 |
| DOI: | 10.1016/S0040-4039(03)01530-2 |