Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

Ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-11, Vol.16 (21), p.9546-9553
Hauptverfasser:	Andrianina Ralambomanana, Dimby, Razafimahefa-Ramilison, Dorothée, Rakotohova, Andry Clément, Maugein, Jeanne, Pélinski, Lydie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Alcohols - chemical synthesis Amino Alcohols - chemistry Amino Alcohols - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Biological and medical sciences Chemical Sciences Diamine Diamines - chemical synthesis Diamines - chemistry Diamines - pharmacology Ethambutol Ferrocene Ferrous Compounds - chemical synthesis Ferrous Compounds - pharmacology Medical sciences Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.
ISSN:	0968-0896 0960-894X 1464-3391
DOI:	10.1016/j.bmc.2008.09.030