Highly inert Cu(II) complexes of C -aryl bifunctional cyclam-picolinates with remarkable 64 Cu-labelling and biodistribution

Cyclam-picolinate chelators were functionalized click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-radiocomplexes. The -aryl functionalization strategy developed here preserves the chemic...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2023-01, Vol.59 (7), p.888-891
Hauptverfasser:	Pineau, Julie, Lima, Luís M P, Le Roy, Marie M, Marionneau-Lambot, Séverine, Cordier, Marie, Le Saëc, Patricia, Zeevaart, Jan Rijn, Driver, Cathryn H S, Faivre-Chauvet, Alain, Le Bris, Nathalie, Tripier, Raphaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Chelating Agents - chemistry Chemical Sciences Cyclams Heterocyclic Compounds - chemistry Picolinic Acids Tissue Distribution
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Cyclam-picolinate chelators were functionalized click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-radiocomplexes. The -aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/D2CC06602E