Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

A randomized trial comparing immunosuppression (horse ATG and cyclosporine) with the same therapy plus eltrombopag showed more rapid and complete responses with the addition of eltrombopag. Severe adverse effects were similar in the two groups. Somatic mutations increased in both groups but did not...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-01, Vol.386 (1), p.11-23
Hauptverfasser:	Peffault de Latour, Régis, Kulasekararaj, Austin, Iacobelli, Simona, Terwel, Sofie R, Cook, Riley, Griffin, Morag, Halkes, Constantijn J.M, Recher, Christian, Barraco, Fiorenza, Forcade, Edouard, Vallejo, Juan-Carlos, Drexler, Beatrice, Mear, Jean-Baptiste, Smith, Alexander E, Angelucci, Emanuele, Raymakers, Reinier A.P, de Groot, Marco R, Daguindau, Etienne, Nur, Erfan, Barcellini, Wilma, Russell, Nigel H, Terriou, Louis, Iori, Anna-Paola, La Rocca, Ursula, Sureda, Anna, Sánchez-Ortega, Isabel, Xicoy, Blanca, Jarque, Isidro, Cavenagh, James, Sicre de Fontbrune, Flore, Marotta, Serena, Munir, Talha, Tjon, Jennifer M.L, Tavitian, Suzanne, Praire, Aline, Clement, Laurence, Rabian, Florence, Marano, Luana, Hill, Anita, Palmisani, Elena, Muus, Petra, Cacace, Fabiana, Frieri, Camilla, van Lint, Maria-Teresa, Passweg, Jakob R, Marsh, Judith C.W, Socié, Gérard, Mufti, Ghulam J, Dufour, Carlo, Risitano, Antonio M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anemia Anemia, Aplastic - drug therapy Anemia, Aplastic - genetics Anemia, Aplastic - therapy Antilymphocyte serum Antilymphocyte Serum - adverse effects Antilymphocyte Serum - therapeutic use Aplastic anemia Benzoates - adverse effects Benzoates - therapeutic use Bone marrow Cyclosporine - adverse effects Cyclosporine - therapeutic use Cyclosporins Drug Therapy, Combination Female Globulins Hematology Humans Hydrazines - adverse effects Hydrazines - therapeutic use Hypotheses Immunosuppression Immunosuppression Therapy Immunosuppressive agents Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Life Sciences Male Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic syndromes Neutrophils Oncology Progression-Free Survival Prospective Studies Pyrazoles - adverse effects Pyrazoles - therapeutic use R&D Receptors, Thrombopoietin - agonists Remission Induction Research & development Response rates Thymocytes Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A randomized trial comparing immunosuppression (horse ATG and cyclosporine) with the same therapy plus eltrombopag showed more rapid and complete responses with the addition of eltrombopag. Severe adverse effects were similar in the two groups. Somatic mutations increased in both groups but did not lead to an increase in leukemia.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2109965