Acute Liver Injury With Therapeutic Doses of Acetaminophen: A Prospective Study

Acute Liver Injury With Therapeutic Doses of Acetaminophen: A Prospective Study

Background and Aims Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2021-05, Vol.73 (5), p.1945-1955
Hauptverfasser: Louvet, Alexandre, Ntandja Wandji, Line Carolle, Lemaître, Elise, Khaldi, Marion, Lafforgue, Claire, Artru, Florent, Quesnel, Benoît, Lassailly, Guillaume, Dharancy, Sébastien, Mathurin, Philippe
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen
Acetaminophen - administration & dosage
Acetaminophen - toxicity
Adult
Age Factors
Alcohol Drinking - adverse effects
Analgesics
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - toxicity
Bilirubin
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - mortality
Drinking behavior
Drug dosages
Drug overdose
Fasting
Female
Hepatology
Humans
Intoxication
Life Sciences
Liver
Male
Middle Aged
Overdose
Patient Acuity
Prospective Studies
Risk Factors
Survival
Young Adult
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Zusammenfassung:Background and Aims Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe APAP‐related ALI in our center were included from 2002 to 2019, either attributable to therapeutic doses or overdose. ALI with therapeutic doses (ALITD) was defined as APAP intake
ISSN:0270-9139
1527-3350
1527-3350
DOI:10.1002/hep.31678