Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.Patients and methods...

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Veröffentlicht in:European journal of cancer (1990) 2018-05, Vol.98, p.1-9
Hauptverfasser: Aparicio, Thomas, Ducreux, Michel, Faroux, Roger, Barbier, Emilie, Manfredi, Sylvain, Lecomte, Thierry, Etienne, Pierre-Luc, Bedenne, Laurent, Bennouna, Jaafar, Phelip, Jean-Marc, François, Eric, Michel, Pierre, Legoux, Jean-Louis, Gasmi, Mohamed, Breysacher, Gilles, Rougier, Philippe, de Gramont, Aimery, Lepage, Côme, Bouché, Olivier, Seitz, Jean-François, Adenis, A, Alessio, A, Aouakli, A, Azzedine, A, Bedjaoui, A, Bidault, A, Blanchi, A, Botton, A, Cadier-Lagnes, A, Fatisse, A, Gagnaire, A, Gilbert, A, Gueye, A, Hollebecque, A, Lemaire, A, Mahamat, A, Marre, A, Patenotte, A, Rotenberg, A, Roussel, A, Thirot-Bidault, A, Votte, A, Weber, A, Zaanan, A, Dupont-Gossart, A C, Villing, A L, Queuniet, A M, Coudert, B, Denis, B, Garcia, B, Lafforgue, B, Landi, B, Leduc, B, Linot, B, Paillot, B, Rhein, B, Winkfield, B, Barberis, C, Becht, C, Belletier, C, Berger, C, Bineau, C, Borel, C, Brezault, C, Buffet, C, Cornila, C, Couffon, C, de la Fouchardière, C, Giraud, C, Lecaille, C, Lepere, C, Lobry, C, Locher, C, Lombard-Bohas, C, Paoletti, C, Platini, C, Rebischung, C, Sarda, C, Vilain, C, Briac-Levaché, C, Auby, D, Baudet-Klepping, D, Bechade, D, Besson, D, Cleau, D, Festin, D, Gargot, D, Genet, D, Goldfain, D, Luet, D, Malka, D, Peré-Vergé, D, Pillon, D, Sevin-Robiche, D, Smith, D, Soubrane, D, Tougeron, D, Zylberait, D, Carola, E, Cuillerier, E
Format: Artikel
Sprache:eng
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Cancer
Humanities and Social Sciences
Life Sciences
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Zusammenfassung:Background: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.Patients and methods: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI
ISSN:0959-8049
DOI:10.1016/j.ejca.2018.03.031