Profile of patients hospitalized in intensive cardiac care units in France: ADDICT-ICCU registry

[Display omitted] •Typology of patients hospitalized in ICCU in France is poorly known.•Acute coronary syndromes represent more than half of admission to ICCU.•A broad array of other cardiovascular disease with comorbidities is seen.•Acute heart failure represents a burden for resource use and mortality.•Large proportion of patients has a good hospital prognosis and low resource use. Intensive cardiac care units (ICCU) were initially developed to monitor ventricular arrhythmias after myocardial infarction. In recent decades, ICCU have diversified their activities. To determine the type of patients hospitalized in ICCU in France. We analysed the characteristics of patients enrolled in the ADDICT-ICCU registry (NCT05063097), a prospective study of consecutive patients admitted to ICCU in 39 centres throughout France from 7th–22nd April 2021. In-hospital major adverse events (MAE) (death, resuscitated cardiac arrest and cardiogenic shock) were recorded. Among 1499 patients (median age 65 [interquartile range 54–74] years, 69.6% male, 21.7% diabetes mellitus, 64.7% current or previous smokers), 34.9% had a history of coronary artery disease, 11.7% atrial fibrillation and 5.2% cardiomyopathy. The most frequent reason for admission to ICCU was acute coronary syndromes (ACS; 51.5%), acute heart failure (AHF; 14.1%) and unexplained chest pain (6.8%). An invasive procedure was performed in 36.2%. “Advanced” ICCU therapies were required for 19.9% of patients (intravenous diuretics 18.4%, non-invasive ventilation 6.1%, inotropic drugs 2.3%). No invasive procedures or advanced therapies were required in 44.1%. Cardiac computed tomography or magnetic resonance imaging was carried out in 12.3% of patients. The median length of ICCU hospitalization was 2.0 (interquartile range 1.0–4.0) days. The mean rate of MAE was 4.5%, and was highest in patients with AHF (10.4%). ACS remains the main cause of admissions to ICCU, with most having a low rate of in-hospital MAE. Most patients experience a brief stay in ICCU before being discharged home. AHF is associated with highest death rate and with higher resource consumption.